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Removing the build-up from wooden salt and pepper shakers is done in much the same way as you would clean glass shakers. Be sure to empty the shakers out and then submerge them in warm soapy water for three to five minutes.
After the salt and pepper shakers have soaked, scrub them gently with a coarse sponge until you've removed all the grime and build-up. Then rinse the shakers and place them in the dish drain to dry.
Once the shakers have dried thoroughly, you can put fresh salt and pepper into the shakers and use them as you normally would!