The best way to clean white sneakers is with an old toothbrush and some form of a cleanser. Murphy's Oil Soap, liquid laundry detergent, Comet, etc. are all good choices. Air dry. Most sneakers can be washed in the washing machine, but it will shorten their lifespan, and may cause some of the glue to come loose. If any stains remain after cleaning, they can be covered up with white shoe polish.